AB165. The role of inflammatory cytokines and MAPK signaling in chronic prostatitis/chronic pelvic pain syndrome with related mental health disorders

© Translational Andrology and Urology. All rights reserved. Transl Androl Urol, 2015;4(S1) www.amepc.org/tau Results: From the samples provided, the top three biomarker combinations (C) returned high sensitivity and specificity of 91.38% and 94.29% from PCDH17 + POU4F2 (C1), 91.38% and 90.00% from PCDH17 + POU4F2 + NID2 (C2), and 93.10% and 92.86% from PCDH17 + POU4F2 + EOMES (C3) consequently. These combinations provide greater sensitivities and specificities than any examined single biomarkers, except for C2, which has a lower specificity compare to POU4F2 (92.86%). Conclusions: Compound biomarker panels were shown to be capable of detecting BlCa effectively by utilizing urine sediment DNA. Due to the performance of higher sensitivity and specificity when compared to single biomarker examinations in BlCa patients and the diverse control groups, these panels are particularly suitable for mass-scale routine BlCa screening.